You can withdraw as many times as you like from your Credit Line as long as you maintain the Loan-to-Value ratio, and you have enough collateral assets in your Nexo account.
Please keep in mind that upon requesting a new loan crypto assets may be automatically transferred from Savings wallet to Credit Line wallet if there is not enough collateral in the Credit Line wallet to support the loan.
Similarly, you can make repayments at any time and, thus, increase the available loan limit in your account.